Oxidative stress and depigmentation

Due to oxidative stress (high concentrations of free radicals) vacuolization and cell death occur.

These include a gradual loss of melanocytes(1)(2)(3)(4) and an abnormally high level of hydrogen peroxide (H2O2) in the epidermis, leading to oxidative stress and oxidation of proteins and lipids.(5)

Keratinocytes in vitiligo lesions have proinflammatory responses, a combination of SOD and Catalase, vitamin E, D3, copper will help to protect cells from damages and help to a normal pigmentation of the skin .

The addition of catalase, vitamin E help to fight oxidative stress.

Concentration of hydrogen peroxide (H2O2) in vitiligo patients

 
H2O2 vitiligo

Concentration of hydrogen peroxide (H2O2) in patients with vitiligo (red) compared to patients without vitiligo (blue)(9)

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