VitiDerm®

Gel and softgels

Vitiligo is characterized by a catalase deficiency that leads to the vacuolization of the melanocytes and keratinocytes.

VitiDerm® is an innovative product from DermoPro.

Oxidative stress and depigmentation

Due to oxidative stress (high concentrations of free radicals) vacuolization and cell death occur.

These include a gradual loss of melanocytes(1)(2)(3)(4) and an abnormally high level of hydrogen peroxide (H2O2) in the epidermis, leading to oxidative stress and oxidation of proteins and lipids.(5)

Keratinocytes in vitiligo lesions have proinflammatory responses, which can be inhibited through the combination of SOD and Catalase.

Concentration of hydrogen peroxide (H2O2) in vitiligo patients

 
Concentration of hydrogen peroxide (H2O2) in patients with vitiligo (red) compared to patients without vitiligo (blue)(9)


Numerous recent studies have pinpointed certain anomalies in patients with skin depigmentation.

In patients with vitiligo, it has been shown that a deficiency in catalase, vitamins and minerals is one of the causes of oxidative stress.(7) (12).

Oxidative stress damages the melanocyte membranes, the cells which are essential for skin pigmentation (6).

Cell damage in patients with vitiligo

Cell damage in vitiligo patients (red) and control subjects (blue) exposed to an increasing concentration of H2O2 (from 1-100 mM). Oxidative stress level and tyrosinase activity in vitiligo patients(8)
 

Restoring the physiological conditions for pigmentation

  • Melon extract : Superoxede dismutase - SOD and catalase

  • Ginkgo Biloba : Prevent cells from oxydative stress like melon

  • Selenium : Contributes to a normal immune system and to protect cells from oxidative stress

  • Vitamins C : Contributes to a normal immune system and to protect cells from oxidative stress

  • Vitamins A : Metabolism of iron (important to vehicule oxygen), protection of DNA, proteins and lipids from oxidative damage
    maintenance of normal skin, maintenance of the normal function of the immune system

  • Vitamin D3 : Normal function of immune system and inflammation response

  • Vitamin E : Contributes to protect cells from oxidative stress, maintenance of the normal function of the immune system, protection of DNA, proteins and lipids from oxidative damage, maintenance of normal skin, regeneration of the reduced form of vitamin C

  • Silica : Enable a normal development of the conective tissue

  • Ascorbyl palmitate : : Contribution to normal energy-yielding metabolism

  • Acerola : Protect DNA and prevent cells from oxidative stress (80 more powerfull than vitamin C)

  • Green tea, calcium carbonate


VitiDerm® topical gel DermoPro latest innovation Innovation with an optimized and more concentrated formula , VitiDerm ® gel ingredients helps to prevent oxydative...detail du VitiDerm® topical gel
VitiDerm® softgelsFormulated with an optimum combination of ingredients VitiDerm® delivers a concentrated cocktail of active substances.(A-B-C).This optimized...detail du VitiDerm® softgels
VitiDerm® 100 ml gel + 2 softgels box 90 VitiDerm® 100 ml gel + 2 softgels boxesFull set with topic plus systemic ensuring best results: - 1 x VitiDerm Gel (Sealed tube, 100 ml)...detail du VitiDerm® 100 ml gel + 2 softgels box 90
UVB Narrowband Lamp Dermalight 80 for Vitiligo treatment"The selective phototherapy (311 nl) has demonstrated efficacy for the treatment of vitiligo and it now tends to supplant the PUVA, and has...detail du UVB Narrowband Lamp Dermalight 80 for Vitiligo treatment
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