Gel and softgels
Vitiligo is characterized by a catalase deficiency that leads to the vacuolization of the melanocytes and keratinocytes.
VitiDerm® is an innovative product from DermoPro.
Oxidative stress and depigmentation
Due to oxidative stress (high concentrations of free radicals) vacuolization and cell death occur.
These include a gradual loss of melanocytes(1)(2)(3)(4) and an abnormally high level of hydrogen peroxide (H2O2) in the epidermis, leading to oxidative stress and oxidation of proteins and lipids.(5)
Keratinocytes in vitiligo lesions have proinflammatory responses, which can be inhibited through the combination of SOD and Catalase.
Concentration of hydrogen peroxide (H2O2) in vitiligo patients
Concentration of hydrogen peroxide (H2O2) in patients with vitiligo (red) compared to patients without vitiligo (blue)(9)
Numerous recent studies have pinpointed certain anomalies in patients with skin depigmentation.
In patients with vitiligo, it has been shown that a deficiency in catalase, vitamins and minerals is one of the causes of oxidative stress.(7) (12).
Oxidative stress damages the melanocyte membranes, the cells which are essential for skin pigmentation (6).
Cell damage in patients with vitiligo
Cell damage in vitiligo patients (red) and control subjects (blue) exposed to an increasing concentration of H2O2 (from 1-100 mM). Oxidative stress level and tyrosinase activity in vitiligo patients(8)
Restoring the physiological conditions for pigmentation
Melon extract : Superoxede dismutase - SOD and catalase
Ginkgo Biloba : Prevent cells from oxydative stress like melon
Selenium : Contributes to a normal immune system and to protect cells from oxidative stress
Vitamins C : Contributes to a normal immune system and to protect cells from oxidative stress
Vitamins A : Metabolism of iron (important to vehicule oxygen), protection of DNA, proteins and lipids from oxidative damage
maintenance of normal skin, maintenance of the normal function of the immune system
Vitamin D3 : Normal function of immune system and inflammation response
Vitamin E : Contributes to protect cells from oxidative stress, maintenance of the normal function of the immune system, protection of DNA, proteins and lipids from oxidative damage, maintenance of normal skin, regeneration of the reduced form of vitamin C
Silica : Enable a normal development of the conective tissue
Ascorbyl palmitate : : Contribution to normal energy-yielding metabolism
Acerola : Protect DNA and prevent cells from oxidative stress (80 more powerfull than vitamin C)
Green tea, calcium carbonate